Nicotine Essay -- Cigarettes Addiction Tobacco Papers

Nicotine posterior smoking has been known for years to impair health of dirty dogrs and nonsmokers exposed to smoke in various ways such as by alter the lungs and circulatory system. Nicotine, present in mainstream and sidestream smoke, is believed to be one of the most poisonous components of tobacco. In 1994, David Kessler, commissioner of the FDA, launched an attack on tobacco companies, claiming they deliberately increased nicotine levels in cigarettes. Nicotine has been shown in various experiments to induce tolerance in smokers by its personal effects on the CNS and dopaminergic receptors. David Kessler believes nicotine to be habit-forming and desires the FDA to regulate nicotine as each drug such as cocaine. If the agency can prove that nicotine is addictive and that the manufacturers of tobacco products have control over the levels of nicotine in their products, the road is able to regulating cigarettes.Although there have been some experiment that disprove nicotines i ndecorous effects, most studies point to nicotine as a very toxic agent. Nicotine is non essential to tobacco products. It is a naturally occurring slightly basic alkaloid with a pyridine and a pyrrolidine ring. It is estimated that the average smoker inhales with each puff, a dose of nicotine similar to .1mg nicotine given intravenously. Nicotines pKa is 9. Its half-life is two hours. Nicotine is converted to its metabolites by the P450 enzyme system and by aldehyde oxidases. Nicotine and its metabolites, such as cotinine, Nnitrosomornicotinine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)1-butanone (NNK) are toxic to humans. As is shown in P4, many an(prenominal) people in the United States smoke. The average mg of nicotine per cigarette has declined in the United States in the1980... ... of Epidemiology.124.633-640(1986). 23.Maritz et al. The Influence of Maternal Nicotine Exposure On the Interalveolar septal Status of Neonatal Rat Lung.Cell Biology International.18.747-754 (1994).24.Rajini et al. Short-Term effects of Sidestream smoking On Respiratory Epithelial Cells of Mice Cell Kinetics.Experimental and utilise Toxicology.22.405-410.25.Maritz et al. Nicotine Exposure Responses of guinea pig II Pneumocytes of Neonatal Rat Pups. American Journal of Pathology.82.124-136(1992) 26.Joad et al. Intrauterine Effects of Sidestream Cigarette Smoke Exposure On Lung Function, Hyperresponsiveness, and Neuroendocrine Cells In Rats.Toxicology and Applied Pharmacology.132.63-71(1994). 27.US Surgeon General(1982) The Health Consequences of Smoking - Cancer.US Public Health Service PHHS.(PHS) 82-50179, US Government Printing Office, Washington, D.C.